Diagnosis: Multiple Myeloma
UAMS / MIRT
Total Therapy 4 Standard Arm
11/24/08 Diagnosis IgG kappa
12/09/08 - Induction # I
12/30/08 MVDTPACE
Stem Cell Collection - 24 Million
Velcade (days 1,5,8 and 11)
Melphalan (day 3)
DTPACE (days 5-8)
12/31/08 - Bridging
1/10/09 Dex / Thal
1/11/09 - Induction # 2
1/27/09 MVDTPACE
Velcade (days 1,4,8 and 11)
Melphalan (day 1)
DTPACE (days 1-4)
2/27/09 - Transplant # 1 (6 million stem cells)
3/17/09 Unfractionated Melphalan 200
Melphalan 200mg/m2 (day -1 )
Dexamethasone 40mg (days -2, -1, 0, and 1)
3/18/10- Bridging
4/12/10 Dex / Thal
(stop Thal. 7 days before Transplant)
4/13/09 Developed DVT
Hospitalized , Vena Cava Filter placed
Lovenox SQ prescribed for blood clots
5/13/09- Transplant # 2 (3 million stem cells)
5/29/09 Unfractionated Melphalan 200
Melphalan 200mg/m2 – ( day -1 ) (BSA Cap of 2.0)
Dexamethasone 40mg (days -2, -1, 0, and 1)
5/30/09- Bridging
7/13/09 Dex / Thal
7/14/09- Consolidation # 1
7/31/09 VDTPACE
Velcade (days 1,4,8 and 11)
DTPACE (days 1-4)
8/6/09 Kyphoplasty T-4
8/7/09- Bridging
9/3/09 Dex / Thal
9/4/09- Consolidation #2
9/21/09 VDTPACE
Velcade (days 1,4,8 and 11)
DTPACE (days 1-4)
11/11/09- Maintenance
10/31/12 VRD (every 28 days x 3 years)
Velcade 1.9mg (days 1,8,15 and 22)
Dexamethasone 20mg (days 1,8,15 and 22)
Revlimid 15mg (days 1-21, off 22 – 28)
Zometa 4mg (every 3 months)
2/4/10 Kyphoplasty
(2) T 11-12
Drug Key:
V= Velcade (Bortezomib)
M= Melphalan (Alkeran)
T = Thalidomide (Thalomid)
D = Dexamethasone (Decadron)
P = Cisplatin (Cisplatinum)
A = Adriamycin (Doxorubicin)
C = Cyclophosphamide (Cytoxan)
E = Etoposide (Eposin)
G = Granulocyte Colony
Stimulating Factor (GCSF)
R = Revlimid (Lenalidomide)
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