My Multiple Myeloma Treatment Roadmap


 Diagnosis: Multiple Myeloma 

UAMS / MIRT

Total Therapy 4 Standard Arm

11/24/08              Diagnosis            IgG kappa

12/09/08 -           Induction # I     
12/30/08              MVDTPACE          
                                Stem Cell Collection -  24 Million
Velcade     (days 1,5,8 and 11)
Melphalan   (day 3)
DTPACE    (days 5-8)

12/31/08 -           Bridging       
1/10/09                Dex / Thal

1/11/09 -              Induction # 2    
1/27/09                MVDTPACE
Velcade    (days 1,4,8 and 11)
Melphalan    (day 1)
DTPACE    (days 1-4)

2/27/09 -              Transplant # 1   (6 million stem cells)                    
3/17/09                Unfractionated Melphalan 200
Melphalan 200mg/m2  (day -1 )
Dexamethasone 40mg (days -2, -1, 0, and 1)

3/18/10-               Bridging                              
4/12/10                 Dex / Thal
                                (stop Thal. 7 days before Transplant)

4/13/09                Developed DVT
                                Hospitalized , Vena Cava Filter placed
                                Lovenox SQ  prescribed  for blood clots

5/13/09-               Transplant # 2   (3 million stem cells)                   
5/29/09                 Unfractionated Melphalan 200
Melphalan 200mg/m2 –   ( day -1 ) (BSA Cap of 2.0)
Dexamethasone 40mg   (days -2, -1, 0, and 1)

5/30/09-               Bridging                              
7/13/09                 Dex / Thal

7/14/09-               Consolidation # 1                           
7/31/09                VDTPACE
Velcade     (days 1,4,8 and 11)
DTPACE      (days 1-4)

8/6/09                   Kyphoplasty   T-4

8/7/09-                 Bridging                              
9/3/09                   Dex / Thal           

9/4/09-                 Consolidation #2                            
9/21/09                VDTPACE
Velcade   (days 1,4,8 and 11)
 DTPACE    (days 1-4)

11/11/09-            Maintenance                                    
10/31/12              VRD       (every 28 days x 3 years)
Velcade 1.9mg   (days 1,8,15 and 22)
Dexamethasone 20mg  (days 1,8,15 and 22)
Revlimid 15mg   (days 1-21, off 22 – 28)
                                Zometa 4mg    (every 3 months)


2/4/10                  Kyphoplasty
                                (2)  T 11-12
               
                Drug Key:

                V= Velcade (Bortezomib)
                M= Melphalan (Alkeran)
                T = Thalidomide (Thalomid)
                D = Dexamethasone (Decadron)
                P = Cisplatin (Cisplatinum)
                A = Adriamycin (Doxorubicin)
                C = Cyclophosphamide (Cytoxan)
                E = Etoposide (Eposin)
                G =  Granulocyte Colony
                        Stimulating Factor (GCSF)
                R =  Revlimid  (Lenalidomide)