My Total Therapy 4 UAMS Treatment Schedule

Hi!  Here is a very myelomic post for MM people. It will make more sense to you than the non-initiated blog readers.If there are questions feel free to respond or  e-mail me at (sean dot murray57 at gmail dot com).

In an e-mail, a MM patient asked me where I was treated and if I would provide details. Well, sure.

I was treated at the University of Arkansas for Medical Sciences' Myeloma Institute for Research & Therapy (MIRT) in Little Rock, AR.    http://myeloma.uams.edu/



The protocol that I followed was Total Therapy 4- Standard Arm. Dx- 11/25/08, IgG kappa, 77.5 % plasma cells at Dx (3% now!) , in Complete Remission. I'll share number progressions in later posts - when I'm convinced that people are actually reading this blog!  : )

          Total Therapy 4: Phase III Trial for Multiple Myeloma

                             

11/24/08         Diagnosis      IgG kappa

12/09/08 -      Induction # 1  
12/30/08         MVDTPACE    
                       Stem Cell Collection -  24 Million
                       Velcade     (days 1,5,8 and 11)
                       Melphalan   (day 3)
                       DTPACE    (days 5-8)

12/31/08 -       Bridging     
1/10/09           Dex / Thal

1/11/09 -         Induction # 2  
1/27/09           MVDTPACE
                       Velcade    (days 1,4,8 and 11)
                       Melphalan    (day 1)
                       DTPACE    (days 1-4)

2/27/09 -        Transplant # 1    (6 million stem cells)      
3/17/09           Unfractionated Melphalan 200
                       Melphalan 200mg/m2  (day -1 )
                       Dexamethasone 40mg (days -2, -1, 0, and 1)

3/18/10-         Bridging       
4/12/10           Dex / Thal
                      (stop Thal. 7 days before Transplant)

4/13/09          Developed DVT
                      Hospitalized , Vena Cava Filter placed
                      Lovenox SQ  prescribed  for blood clots

5/13/09-        Transplant # 2     (3 million stem cells)      
5/29/09          Unfractionated Melphalan 200
                      Melphalan 200mg/m2 ( day -1 )(BSA Cap of 2.0)
                      Dexamethasone 40mg   (days -2, -1, 0, and 1)

5/30/09-        Bridging       
7/13/09         Dex / Thal

7/14/09-        Consolidation # 1      
7/31/09         VDTPACE
                     Velcade (days 1,4,8 and 11)
                     DTPACE      (days 1-4)

8/6/09           Kyphoplasty
                     (1)  T-4

8/7/09-          Bridging       
9/3/09           Dex / Thal  
                   
9/4/09-         Consolidation # 2      
9/21/09         VDTPACE
                     Velcade (days 1,4,8 and 11)
                     DTPACE  (days 1-4)

11/11/09-     Maintenance           
10/31/12       VRD (every 28 days x 3 years)
                     Velcade 1.9mg   (days 1,8,15 and 22)
                     Dexamethasone 20mg  (days 1,8,15 and 22)
                     Revlimid 15mg   (days 1-21, off 22 – 28)
                     Zometa 4mg    (every 3 months)

2/4/10          Kyphoplasty   
                     (2) T 11-12

    Drug Key:

    V= Velcade
    M= Melphalan
    T = Thalidomide
    D = Dexamethasone
    P = Cisplatin
    A = Adriamycin
    C = Cyclophosphamide
    E = Etoposide
    G =  Granulocyte Colony
               Stimulating Factor
     R =  Revlimid,

What a year! All in all, I have fared well and feel pretty darn good. I still experience pain, neuropathy in my feet and hands, but I continue to progress. The treatment, as promised, was aggressively rough, but I'm still standing! Going to UAMS was a good decision for me.

graphic (c) UAMS/MIRT  used with permission